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Its in the news that Sepracor, the maker of the drug has unveiled encouraging preliminary results from its second six-month, phase IIIb/IV safety and efficacy study of Lunesta in insomnia, confirming previous study findings.

The study included 828 patients with chronic insomnia, augments the findings in Sepracor's first landmark, six-month study of Lunesta (eszopiclone). This long-term study included a two-week discontinuation phase, which showed no evidence of treatment-related rebound insomnia or withdrawal symptoms. The study proves the effectiveness of this drug.

It was found that the nightly use of Lunesta 3mg resulted in statistically significant improvement compared with placebo in patient-reported measures of sleep latency, sleep maintenance, total sleep time and sleep quality.

Patients treated with Lunesta also reported improved ability to function, improved daytime alertness, improved ability to concentrate, and improved sense of physical well-being, versus placebo. These differences were apparent in the first month of treatment and were maintained throughout six months of nightly treatment. "This replication of results in the second six-month, double-blind, placebo-controlled study of eszopiclone is noteworthy," said Dr John Winkelman, associate director for the sleep disorders program at Brigham and Women's Hospital, Boston. "This study should provide the medical community with confidence in the findings of the first six-month study and raise the bar in examining insomnia agents for long-term use."

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